THE OUTER MEMBRANE PROTEIN A (ompA) OF YERSINIA PESTIS IS NOT REQUIRED FOR VIRULENCE IN MICE AND RATS
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چکیده
منابع مشابه
DsbA is required for stable expression of outer membrane protein YscC and for efficient Yop secretion in Yersinia pestis.
The role of the periplasmic disulfide oxidoreductase DsbA in Yop secretion was investigated in Yersinia pestis. A Y. pestis dsbA mutant secreted reduced amounts of the V antigen and Yops and expressed reduced amounts of the full-sized YscC protein. Site-directed mutagenesis of the four cysteine residues present in the YscC protein resulted in defects similar to those found in the dsbA mutant. T...
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Yersinia pestis, the causative agent of plague, must survive in blood in order to cause disease and to be transmitted from host to host by fleas. Members of the Ail/Lom family of outer membrane proteins provide protection from complement-dependent killing for a number of pathogenic bacteria. The Y. pestis KIM genome is predicted to encode four Ail/Lom family proteins. Y. pestis mutants specific...
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A strain of Yersinia pseudotuberculosis which harbors a 63-kilobase plasmid was found to cause a lethal infection in Swiss albino mice. The rate of infection paralleled the ability of the pathogenic organism to attach to a monolayer of HeLa cells. One novel outer membrane protein (protein 1) with a molecular weight of 140,000 was found to be associated with the possession of the 63-kilobase pla...
متن کاملRfaL is required for Yersinia pestis type III secretion and virulence.
Yersinia pestis, the causative agent of plague, uses a type III secretion system (T3SS) to inject cytotoxic Yop proteins directly into the cytosol of mammalian host cells. The T3SS can also be activated in vitro at 37°C in the absence of calcium. The chromosomal gene rfaL (waaL) was recently identified as a virulence factor required for proper function of the T3SS. RfaL functions as a ligase th...
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ژورنال
عنوان ژورنال: Russian Journal of Infection and Immunity
سال: 2019
ISSN: 2313-7398,2220-7619
DOI: 10.15789/2220-7619-2018-4-5.5